Focused Ultrasound Therapy

Early Stage square

Focused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with muscle atrophy. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body and stimulates muscle contraction. This has been shown in preclinical studies, but more work is needed before widespread clinical availability is expected.

The primary options for treatment of muscle atrophy are dependent on the perceived cause and include invasive surgery.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications and lower cost.

Advantages:

  • Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.
  • Focused ultrasound can reach the desired target without damaging surrounding tissue.
  • It can be repeated, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of muscle atrophy.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for muscle atrophy is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Matsumoto Y, Nakano J, Oga S, Kataoka H, Honda Y, Sakamoto J, Okita M. The non-thermal effects of pulsed ultrasound irradiation on the development of disuse muscle atrophy in rat gastrocnemius muscle. Ultrasound Med Biol. 2014

Okita M, Nakano J, Kataoka H, Sakamoto J, Origuchi T, Yoshimura T. Effects of therapeutic ultrasound on joint mobility and collagen fibril arrangement in the endomysium of immobilized rat soleus muscle. Ultrasound Med Biol. 2009 Feb;35(2):237-44.

W. J. Tyler, Y. Tufail, M. Finsterwald, M. L. Tauchmann, E. J. Olson, and C. Majestic, “Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound.,” PLoS ONE, vol. 3, no. 10, Oct. 2008.

Click here for additional references from PubMed.

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