Foundation Funded Research Projects

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Showing 100 out of 168 research projects
Category Project Name (Click on the project name for more info) Primary Research Site Principal Investigator Funding Dates Program
Acoustic activation of the GBM-brain microenvironment for improved T-cell...
    Apr 01, 2020 - Apr 01, 2022 Immunotherapy
    Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening...
      Mar 18, 2020 - Mar 17, 2021 Brain Program
      Activating specific cytotoxic T-cells by HIFU and systemic immunotherapy in...
        Jan 28, 2020 - Feb 01, 2021 Immunotherapy
        The Needle-less Nerve Block: Targeted Non-Invasive Analgesia with Ultrasonic...
          Jan 23, 2020 - Apr 22, 2021 Research Award
          Adjuvant Focused Ultrasound to Promote Immunotherapy Response for...
            Nov 22, 2019 - May 21, 2022 Immunotherapy
            Development of Novel Porcine Models of Orthotopic Pancreatic Cancer for FUS and...
              Nov 12, 2019 - Nov 11, 2020 Research Award
              Histotripsy tumor ablation-mediated immune-stimulation
                Nov 06, 2019 - Nov 06, 2020 Immunotherapy
                A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier...
                  Oct 31, 2019 - Oct 30, 2021 Brain Program
                  Alzheimer’s Disease A Phase I/IIa Study: Feasibility of Blood-Brain Barrier Opening in the...
                    Oct 30, 2019 - Oct 29, 2021 Brain Program
                    MRI of Skull Heating During Focused Ultrasound Neurosurgery
                      Oct 24, 2019 - Jan 24, 2022 Brain Program
                      MRI Guidance of Focused Ultrasound Neurosurgery
                        Oct 24, 2019 - Jan 24, 2022 Brain Program
                        Development of Novel Acoustic Coupling Media to Improve Image Guidance and...
                          Oct 24, 2019 - Jan 24, 2021 Research Award
                          Focused ultrasound stimulation of the immune response in a breast cancer model
                            Oct 16, 2019 - Oct 16, 2020 Immunotherapy
                            Focused ultrasound stimulation of the immune response in cancer models
                              Oct 16, 2019 - Oct 16, 2020 Immunotherapy
                              Transcranial Histotripsy for Treatment of Brain Tumors – Initial In-vivo Pig S...
                                Oct 01, 2019 - Sep 30, 2020 Brain Program
                                Investigating the Feasibility of Targeting Temporal Lobe using Transcranial...
                                  Sep 13, 2019 - Sep 12, 2020 Brain Program
                                  Blood Brain Barrier (BBB) Opening of Rat by Laser-generated Focused Ultrasound...
                                    Sep 10, 2019 - Mar 10, 2021 Brain Program
                                    aCD40 + ablation trial
                                      Sep 01, 2019 - Sep 01, 2020 Immunotherapy
                                      Treating veterinary cancer patients with focused ultrasound
                                        Jun 01, 2019 - Jun 01, 2020 Veterinary
                                        Non-Invasive Surgical Treatment of Lung Cancer
                                          May 21, 2019 - Jul 20, 2020 Research Award
                                          FUS for therapy of Neuromyelitis Optica – an inflammatory demyelinating d...
                                            Mar 25, 2019 - Mar 24, 2020 Research Award
                                            Brain tumors, Glioblastoma Focused ultrasound immunomodulation for pancreatic cancer
                                              Mar 12, 2019 - Mar 12, 2020 Immunotherapy
                                              Brain, General Microbubble enhanced FUS treatments in the brain: impact of bubble distribution...
                                                Mar 01, 2019 - Mar 01, 2020 Brain Program
                                                Convective skin-cooling device for use with existing MRgFUS systems to prevent...
                                                  Feb 28, 2019 - Nov 01, 2019 Research Award
                                                  Microbubble distribution in the brain: a real-time intra-operative map to...
                                                    Feb 21, 2019 - Feb 21, 2020 Brain Program
                                                    Parkinson’s Disease MRGFUS GENE DELIVERY FOR NEUROPROTECTION IN PARKINSON'S DISEASE
                                                        Jan 18, 2019 - Jan 18, 2020 Brain Program
                                                        Development of a turnkey USgFUS preclinical research platform
                                                          Jan 04, 2019 - Jan 03, 2020 Research Award
                                                          Drug delivery strategies using drug-loaded extracellular vesicles generated by...
                                                            Dec 11, 2018 - Dec 10, 2019 Research Award
                                                            Movement Disorders, General Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor...
                                                              Sep 28, 2018 - Sep 27, 2019 Research Award
                                                              Psychiatric disorders A Phase 1 Trial of MR-guided Focused Ultrasound (MRgFUS) Bilateral Capsulotomy...
                                                                Sep 27, 2018 - Sep 26, 2020 Brain Program
                                                                Liver tumors Non-invasive Focused Ultrasound Ablation for the Treatment of...
                                                                  Sep 13, 2018 - Aug 30, 2020 Research Award
                                                                  Non-invasive varicose vein treatment by HIFU under ultrasound guidance: Phase...
                                                                    Sep 13, 2018 - Sep 12, 2019 Research Award
                                                                    Psychiatric disorders Phase I trial of MR-guided Focused Ultrasound (MRgFUS) bilateral capsulotomy...
                                                                      Jun 05, 2018 - Jun 04, 2020 Brain Program
                                                                      Brain tumors, General Safety study: sonodynamic therapy with 5-ALA in a porcine model
                                                                        Jun 05, 2018 - Jun 05, 2019 Brain Program
                                                                        Brain tumors, Glioblastoma Safety evaluation of irinotecan delivery to a rat glioma model using a clinical...
                                                                          Jun 04, 2018 - Aug 04, 2019 Research Award
                                                                          Epilepsy Focused ultrasound thalamotomy for the prevention of secondary generalization...
                                                                            Jun 01, 2018 - May 31, 2018 Brain Program
                                                                            Brain tumors, General Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (9L Line)
                                                                                Apr 24, 2018 - Apr 24, 2019 Brain Program
                                                                                Brain tumors, General Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98...
                                                                                    Apr 06, 2018 - Apr 06, 2019 Brain Program
                                                                                    Brain, General Sonodynamic therapy for treatment of C6 glioma in a rat model proof-of-concept...
                                                                                      Apr 04, 2018 - Oct 04, 2018 Brain Program
                                                                                      Stroke, Thromboembolic Selective opening of the blood brain barrier using focused ultrasound combined...
                                                                                        Apr 04, 2018 - Apr 04, 2019 Brain Program
                                                                                        Brain, General Focused ultrasound for treatment of deep-seated cerebral cavernous malformations
                                                                                          Mar 26, 2018 - Mar 26, 2019 Brain Program
                                                                                          Epilepsy Use of low-intensity focused ultrasound for the non-invasive, focal...
                                                                                            Mar 18, 2018 - Jun 18, 2018 Research Award
                                                                                            Soft tissue tumors Investigation of the immunostimulatory response to high intensity focused...
                                                                                              Mar 12, 2018 - Mar 01, 2020 Veterinary
                                                                                              Back & neck pain Focused ultrasound mediated neuromodulation for the treatment of spinal cord...
                                                                                                Mar 05, 2018 - Mar 05, 2019 Brain Program
                                                                                                Investigation of focused ultrasound mediated enhancement of chronic non-...
                                                                                                  Feb 12, 2018 - Sep 15, 2020 Veterinary
                                                                                                  General, Technology Laser-generated Focused Ultrasound Transducer for Transcranial Applications
                                                                                                    Feb 08, 2018 - Apr 22, 2019 Brain Program
                                                                                                    General, Technology Use of shock-wave exposures for accelerating thermal ablation of targeted...
                                                                                                      Feb 07, 2018 - Apr 06, 2019 Research Award
                                                                                                      Bladder tumors Focused Ultrasound Mediated Drug Delivery across the Urothelium
                                                                                                        Feb 06, 2018 - Feb 05, 2019 Research Award
                                                                                                        Pancreatic tumors Focused Ultrasound Driven Drug Release From Theranostic Nanoparticles For The...
                                                                                                          Jan 24, 2018 - Jan 24, 2019 Research Award
                                                                                                          Accessibility and Benefit of FUS treatment for inoperable Lung Cancer Patients,...
                                                                                                            Dec 14, 2017 - Feb 13, 2019 Research Award
                                                                                                            Alzheimer’s Disease Effects of FUS on CNS Uptake and Efficacy of an Anti-Amyloid Antibody in Aged...
                                                                                                              Nov 30, 2017 - Mar 30, 2018 Research Award
                                                                                                              Acoustic Backscatter-based 3D Mapping of Cavitation and Skull Surface in...
                                                                                                                Oct 31, 2017 - Dec 31, 2018 Research Award
                                                                                                                Back & neck pain Safety and initial feasibility of using the Neurolyser XR device for the...
                                                                                                                  Sep 26, 2017 - Mar 25, 2019 Research Award
                                                                                                                  Parkinson’s Disease MRgFUS Blood-Brain Barrier Drug Delivery with AAV2 Gene Therapy Microbubble...
                                                                                                                    Sep 01, 2017 - Aug 31, 2018 Research Award
                                                                                                                    Safety and Effectiveness of Sacroiliac Joint Palliation in Swine using MRgFUS
                                                                                                                      Jul 01, 2017 - Jun 30, 2018 Research Award
                                                                                                                      Bone, Non-metastases Comparative Study - FUS vs. RF ablation
                                                                                                                        Jun 01, 2017 - May 31, 2020 Liver/Pancreas Program
                                                                                                                        Brain tumors, Glioblastoma Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
                                                                                                                          May 17, 2017 - Nov 17, 2017 Immunotherapy
                                                                                                                          Brain tumors, Metastasis Focused Ultrasound to Enhance Immunotherapy for Metastatic Brain Melanoma
                                                                                                                            May 05, 2017 - Sep 04, 2018 Immunotherapy
                                                                                                                            Brain tumors, Glioblastoma Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
                                                                                                                              May 01, 2017 - Nov 01, 2017 Immunotherapy
                                                                                                                              Patterning of bone regeneration via ultrasound activation of heat shock-...
                                                                                                                                Mar 01, 2017 - Feb 28, 2018 Research Award
                                                                                                                                Parkinson’s Disease A Prospective, Randomized, Sham Controlled Study to Evaluate the Safety and...
                                                                                                                                  Mar 01, 2017 - Sep 01, 2020 Brain Program
                                                                                                                                  Brain tumors, General A Feasibility Safety Study Using the ExAblate 4000 system in Management of...
                                                                                                                                    Feb 27, 2017 - Feb 26, 2019 Brain Program
                                                                                                                                    Acoustic Parameters of Bone as a function of HU and MRI
                                                                                                                                      Feb 20, 2017 - Feb 21, 2018 Brain Program
                                                                                                                                      Neuropathic pain Phase 1 Clinical Trial of MR Guided Focused Ultrasound (FUS) Thalamotomy of...
                                                                                                                                        Jan 19, 2017 - Jul 19, 2019 Brain Program
                                                                                                                                        Alzheimer’s Disease A Study to Evaluate the Safety and Feasibility of Blood-Brain Barrier (BBB)...
                                                                                                                                          Jan 12, 2017 - Jan 11, 2019 Brain Program
                                                                                                                                          Real-time Treatment Monitoring by Diffusion MRI
                                                                                                                                            Nov 29, 2016 - Nov 28, 2017 Brain Program
                                                                                                                                            Brain tumors, Glioblastoma Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
                                                                                                                                              Nov 29, 2016 - May 19, 2017 Brain Program
                                                                                                                                              Ultrasound-induced immune response on breast cancer
                                                                                                                                                Nov 28, 2016 - Nov 28, 2020 Immunotherapy
                                                                                                                                                Brain tumors, Glioblastoma Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
                                                                                                                                                  Nov 07, 2016 - Nov 07, 2017 Brain Program
                                                                                                                                                  Brain, General FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals
                                                                                                                                                    Oct 01, 2016 - Sep 30, 2017 Research Award
                                                                                                                                                    Pancreatic tumors Defining Basic Properties of Physical Immunotherapy using HIFU and Immune...
                                                                                                                                                      Sep 07, 2016 - Jun 07, 2019 Immunotherapy
                                                                                                                                                      Brain tumors, Glioblastoma Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
                                                                                                                                                        Aug 15, 2016 - Feb 15, 2017 Immunotherapy
                                                                                                                                                        Parkinson’s Disease Antibody Delivery Through the BBB Opening in an Alpha-Synuclein Model
                                                                                                                                                          Aug 15, 2016 - Oct 15, 2017 Brain Program
                                                                                                                                                          Massively Parallel Nonlinear Ultrasound Simulation of Histotripsy in the Brain
                                                                                                                                                            Jul 18, 2016 - Jul 18, 2017 Brain Program
                                                                                                                                                            Liver tumors A novel genetic reprogramming therapy for hepatocellular carcinoma using...
                                                                                                                                                              Jul 01, 2016 - May 31, 2020 Veterinary
                                                                                                                                                              Epilepsy A Feasibility Study to Evaluate Safety and Initial Effectiveness or MR-Guided...
                                                                                                                                                                Jun 16, 2016 - Jun 16, 2018 Brain Program
                                                                                                                                                                Brain tumors, Glioblastoma Ultrasound-mediated delivery of siRNA for enhancing temozolomide efficacy...
                                                                                                                                                                  Jun 01, 2016 - Dec 15, 2017 Research Award
                                                                                                                                                                  Parkinson’s Disease Minimally-Invasive Therapy for Parkinson’s Disease Achieved by the Focused U...
                                                                                                                                                                    Feb 04, 2016 - Feb 03, 2017 Brain Program
                                                                                                                                                                    Brain, General Development and Calibration of MR Techniques for In-Vivo Bone Thermometry
                                                                                                                                                                      Feb 01, 2016 - Aug 16, 2018 Brain Program
                                                                                                                                                                      General, Cancer Ultrasound ablation combined with immunotherapy: priming to enhance efficacy
                                                                                                                                                                        Feb 01, 2016 - Jan 31, 2017 Brain Program
                                                                                                                                                                        Alzheimer’s Disease Effects of FUS on CNS Uptake and Efficacy of an Anti-Amyloid Antibody in Aged...
                                                                                                                                                                          Feb 01, 2016 - Jan 31, 2017 Brain Program
                                                                                                                                                                          Brain, General Neuro Focused Ultrasound MR Coil Fabrication and Testing
                                                                                                                                                                            Jan 06, 2016 - Apr 06, 2018 Brain Program
                                                                                                                                                                            Kidney tumors Evaluation of the Systemic Response to Boiling Histotripsy Treatment for Renal...
                                                                                                                                                                              Dec 01, 2015 - Apr 30, 2017 Research Award
                                                                                                                                                                              Brain tumors, General A Chronic Pig Study of Transcranial Histotripsy for Treatment of Brain Tumors
                                                                                                                                                                                Nov 11, 2015 - Dec 18, 2015 Brain Program
                                                                                                                                                                                Brain, General Neuronavigation-guided and Ultrasound-Monitored Human BBB-opening Focused...
                                                                                                                                                                                  Nov 01, 2015 - Oct 31, 2016 Brain Program
                                                                                                                                                                                  General, Cancer The Focused ultrasound mediated immune responses in metastatic melanoma
                                                                                                                                                                                    Nov 01, 2015 - Nov 01, 2017 Brain Program
                                                                                                                                                                                    Brain, General Transcranial Histotripsy for Treatment of Brain Tumors
                                                                                                                                                                                      Oct 21, 2015 - Feb 21, 2016 Brain Program
                                                                                                                                                                                      Brain, General Method for fully 3D volumetric thermometry, with application to transcranial...
                                                                                                                                                                                        Oct 09, 2015 - Oct 08, 2016 Brain Program
                                                                                                                                                                                        Back & neck pain Low Intensity Pulsed Ultrasound (LIPUS) for the Treatment of Spinal Disc...
                                                                                                                                                                                          Oct 01, 2015 - Sep 30, 2016 Research Award
                                                                                                                                                                                          Bone, Non-metastases Pediatric Focused Ultrasound Computational Data Center and Registry
                                                                                                                                                                                            Oct 01, 2015 - Dec 31, 2017 Research Award
                                                                                                                                                                                            Brain, General Thermal Dose Experiment in a Pig Model
                                                                                                                                                                                              Jul 24, 2015 - Feb 19, 2016 Brain Program
                                                                                                                                                                                              Movement Disorders, General Modulated focused ultrasound for treatment of de-myelinating axons in multiple...
                                                                                                                                                                                                Jun 01, 2015 - Nov 30, 2016 Research Award
                                                                                                                                                                                                Atrial Fibrillation Trans-Esophageal Cardiac Ablation Using High Intensity Focused Ultrasound: A...
                                                                                                                                                                                                  Jun 01, 2015 - Nov 30, 2016 Research Award
                                                                                                                                                                                                  Brain tumors, Metastasis Enhancing immune therapy for brain metastases with focused ultrasound
                                                                                                                                                                                                    Jun 01, 2015 - May 31, 2018
                                                                                                                                                                                                    Parkinson’s Disease A feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate...
                                                                                                                                                                                                        Mar 03, 2015 - Sep 03, 2016 Brain Program
                                                                                                                                                                                                        Back & neck pain Treatment of facetogenic lumbar back pain
                                                                                                                                                                                                          Mar 02, 2015 - Mar 01, 2016 Research Award
                                                                                                                                                                                                          General, Cancer Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 2: P...
                                                                                                                                                                                                            Feb 12, 2015 - Feb 11, 2016 Brain Program
                                                                                                                                                                                                            Parkinson’s Disease Focused Ultrasound for Increased Delivery of Intranasal DNA Nanoparticles to...
                                                                                                                                                                                                              Feb 01, 2015 - Jan 31, 2017 Research Award
                                                                                                                                                                                                              Brain, General Enhancement of FUS Mediated Delivery of Stem Cells to Brain
                                                                                                                                                                                                                Feb 01, 2015 - Jan 31, 2016 Research Award
                                                                                                                                                                                                                Brain tumors, General MR-Guided Ultrasound Neurosurgery for the Treatment of Brain Tumors
                                                                                                                                                                                                                  Nov 10, 2014 - Nov 09, 2016 Brain Program
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