Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98 Line)

Project Name: Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98 Line)
Status: Active
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Apr 06, 2018
Funding Program: Brain Program
Funding Period: Apr 06, 2018 - Apr 06, 2019
Amount Awarded: $44,387.23
Category: Brain tumors, General

Abstract

• Determine the dose-response relationship between inertial cavitation (induced by activation of MBs with MR image-guided FUS) and tumor blood flow and/or perfused tumor volume in rat gliomas • Determine whether FUS-MB cavitation treatment inhibits tumor growth and improves animal survival. If it does, determine whether these responses depend on FUS pressure level • Determine whether the most beneficial FUS+MB treatment affects intra-tumor immune cell representation at the terminal time point • Determine whether any/all of the above depend upon tumor model

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