Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors.

Project Name: Investigation of the immunostimulatory response to high intensity focused ultrasound in dogs with naturally-occurring solid tumors.
Status: Active
Primary Site: Virginia Polytechnic Institute and State University
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Mar 12, 2018
Funding Program: Veterinary
Funding Period: Mar 12, 2018 - Mar 01, 2020
Amount Awarded: $176,402.00
Category: Soft tissue tumors

Abstract

We will use ultrasound-guided HIFU to characterize its effects on the immune system at the local and systemic level. We believe that focused ultrasound will result in a strong immune stimulation, which will be detectable within the tumor tissue, peri-tumoral tissue, and peripheral blood. We will recruit 20 dogs with solid tumors, deliver a single HIFU treatment, and assess the immune response at Day 4 after treatment, using the pretreatment time-point (Day 0) as baseline.

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