Selective opening of the blood brain barrier using focused ultrasound combined with systemic delivery of neural progenitor cells and mitrochondria post-stroke

Project Name: Selective opening of the blood brain barrier using focused ultrasound combined with systemic delivery of neural progenitor cells and mitrochondria post-stroke
Status: Closed
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Apr 04, 2018
Funding Program: Brain Program
Funding Period: Apr 04, 2018 - Apr 04, 2019
Amount Awarded: $167,553.20
Category: Stroke, Thromboembolic

Abstract

Focused ultrasound (FUS) has recently been demonstrated to have the efficacy and safety for selective targeting of deep-seated regions of the brain (Elias et al., 2016). The objective of the proposed research program is to utilize FUS to selectively open the blood brain barrier (BBB) at the site of stroke-induced injury. We will then systemically deliver a prospectively isolated and purified population of mouse neural stem cells (NSC) tagged with a fluorescent marker and study the rate of integration of this population of cells into the site of selective BBB opening and in the rest of the brain. A control group will be used to assess the efficacy of FUS-induced BBB opening. If FUS can be safely used to selectively open the BBB for systemically administered cell transplantation into the CNS, it would provide a minimally invasive modality for treatment and regeneration in the post-stroke period.

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