Microbubble distribution in the brain: a real-time intra-operative map to optimize FUS treatment

Project Name: Microbubble distribution in the brain: a real-time intra-operative map to optimize FUS treatment
Status: Closed
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Feb 21, 2019
Funding Program: Brain Program
Funding Period: Feb 21, 2019 - Feb 21, 2020
Amount Awarded: $33,150.00

Abstract

Microbubbles (MBs) are currently used in different clinical settings, especially for imaging with the contrast-enhanced ultrasound (CEUS) technique. Recently, MBs have been used during neurosurgical procedures to highlight different pathologies. MBs therapeutic usage is envisaged in combination with focused ultrasound (FUS) to perform treatments such as blood brain barrier (BBB) opening and MBs enhanced ablation. However, distribution and localization of MBs in different areas of the normal human brain and in pathological conditions, and their concentration over time are not yet fully known. FUS treatments are therefore limited because of this lack of data.

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