Convective skin-cooling device for use with existing MRgFUS systems to prevent skin burns

Project Name: Convective skin-cooling device for use with existing MRgFUS systems to prevent skin burns
Status: Active
Primary Site: University of Utah
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Feb 28, 2019
Funding Program: Research Award
Funding Period: Feb 28, 2019 - Nov 01, 2019
Amount Awarded: $94,365.00

Abstract

The adverse event of skin burns and the restrictions caused by multi-hour treatment times continue to limit the clinical efficacy and cost effectiveness of MRgFUS thermal therapies. This proposal directly addresses these unmet needs with two primary aims. Aim 1 includes design and fabrication of a prototype cooling device, testing of clinically identified design specifications, and initial experimental validation ex vivo tissue experiments. This conformable skin-cooling device will reduce the potential for skin burns in desmoid tumor and other MRgFUS treatments. Aim 2 will assess the skin cooling device on a pre-clinical MRgFUS system with rabbit and pig studies and will integrate the device with the clinical ExAblate 2100 system. The ultimate goal of the device design is to be MRgFUS system independent. This may require a modular design that allows for both clinical and veterinarian applications. The completion of this proposal will deliver the engineering schematic, parts list and use manual of the completed device, validation data and install a single device at the Focused Ultrasound Center of Excellence at Stanford University.

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