Histotripsy tumor ablation-mediated immune-stimulation

Project Name: Histotripsy tumor ablation-mediated immune-stimulation
Status: Active
Primary Site: University of Michigan
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Nov 06, 2019
Funding Program: Immunotherapy
Funding Period: Nov 06, 2019 - Nov 06, 2020
Amount Awarded: $112,008.00

Abstract

Immunotherapy has radically altered the prognostic outlook for patients with relatively immunogenic cancers like melanoma and lung cancer; however, cancers that are less conspicuous to the immune system have been obstinately resistant to immunotherapy. Histotripsy uses high-intensity, focused ultrasound pulses to generate inertial cavitation to cause cellular disruption, liquefying the target tumor to acellular debris. Preliminary results show that histotripsy stimulates local, regional, and systemic immune responses; histotripsy stimulates abscopal effects in the immunosuppressive murine hepatocellular model. We hypothesize that histotripsy can break the ability of cancers to avoid immune detection, sensitizing previously resistant cancers to immunotherapy.

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