Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 2: Proof-of-concept ultrasound study and Step 3: Optimization and comparative effectiveness study

Project Name: Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 2: Proof-of-concept ultrasound study and Step 3: Optimization and comparative effectiveness study
Status: Complete
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Feb 12, 2015
Funding Program: Brain Program
Funding Period: Feb 12, 2015 - Feb 11, 2016
Amount Awarded: $109,137.76
Category: General, Cancer

Abstract

The dismal survival rate for patients with intracranial tumors combined with the need for a safer and more effective treatment modality that is non-invasive, deep-penetrating, and less prone to infection and damage to surrounding tissues makes sonodynamic therapy (SDT) an attractive area of research. Ultrasound therapy has been shown to induce apoptosis of tumor cells when used in conjunction with various sonosensitizers. The aim of Step 1 was to determine whether the sonosensitizers 5-ALA, IcG and Verteporfin can be effectively delivered to the subcutaneous C6 glioma rat model (a readily available model). The aim of Step 2 (this study) is a proof-of-concept study of ultrasound-induced hyperthermia (low-level heating) as a means to activate 5-ALA and Verteporfin (IcG was not feasible in view of the quick washout period demonstrated in Step 1) to cause cell death will be completed. Finally, a larger study (Step 3) will be completed to compare the effectiveness of these sonosensitizers, identify a “best” sonosensitizer, and further optimize ultrasound parameters including frequency, which could ultimately help move this work towards a clinical trial.

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