Microbubble cloud formation from ultrasound contrast agents during histotripsy pulses

Project Name: Microbubble cloud formation from ultrasound contrast agents during histotripsy pulses
Status: Complete
Primary Site: University of Cincinnati
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Aug 01, 2014
Funding Program: Research Award
Funding Period: Aug 01, 2014 - Nov 30, 2015
Amount Awarded: $107,520.00

Abstract

The stochastic nature of microbubble activity makes the development of regulatory standards difficult for cavitation-based ultrasound therapies. We propose to develop in vitro and in silico models to assess the area, location, and type of microbubble activity and ablation during histotripsy pulses. These data will elucidate a FDA regulatory framework for histotripsy devices, which will profoundly impact the advancement of clinical use of focused ultrasound.

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