A novel genetic reprogramming therapy for hepatocellular carcinoma using focused ultrasound-guided delivery of microRNA

Project Name: A novel genetic reprogramming therapy for hepatocellular carcinoma using focused ultrasound-guided delivery of microRNA
Status: Active
Primary Site: Stanford University School of Medicine
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Jul 01, 2016
Funding Program: Veterinary
Funding Period: Jul 01, 2016 - May 31, 2020
Amount Awarded: $100,000.00
Category: Liver tumors

Abstract

New approaches to treating hepatocellular carcinoma (HCC) are critically needed as therapeutic options are very limited and recurrence is common. Here, we explore a novel genetic reprogramming approach to effectively treat HCC with reduced recurrence risk by delivering therapeutic microRNAs using a focused ultrasoundguided and microbubble facilitated drug delivery platform. Guided by a roadmap predicting the treatment outcomes in real-time, this approach allows adjustment and optimization of therapeutic delivery into the entire tumor volume, thereby reducing the risk of recurrence from inappropriately treated regions.

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