Modulated focused ultrasound for treatment of de-myelinating axons in multiple sclerosis lesions – pilot animal studies

Project Name: Modulated focused ultrasound for treatment of de-myelinating axons in multiple sclerosis lesions – pilot animal studies
Status: Complete
Primary Site: University of Washington
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Jun 01, 2015
Funding Program: Research Award
Funding Period: Jun 01, 2015 - Nov 30, 2016
Amount Awarded: $100,000.00
Category: Movement Disorders, General

Abstract

Multiple sclerosis is a debilitating disease whose symptoms arise from de-myelination of axons within brain tissue with an attendant loss of central and peripheral function. We among others have shown that transcranial delivery of pulsed focused ultrasound (pFU) can non-destructively activate central neural circuits. Others have shown enhanced myelin remodeling of axons activated by laser light in an optogenetic mouse model. We hypothesize that pFU activation of axons within MS lesions in a rodent model will decrease their de-myelination and increase their re-myelination. If successful, this non-invasive therapy may lead to rapid advancements in the treatment of MS and other de-myelinating neurological disorders.

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