Antibody Delivery Through the BBB Opening in an Alpha-Synuclein Model

Project Name: Antibody Delivery Through the BBB Opening in an Alpha-Synuclein Model
Status: Complete
Primary Site: Columbia University
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Aug 15, 2016
Funding Program: Brain Program
Funding Period: Aug 15, 2016 - Oct 15, 2017
Amount Awarded: $100,000.00
Category: Parkinson’s Disease

Abstract

In the proposed study, we will examine the capability of focused ultrasound (FUS) to allow antibody delivery across the induced BBB opening and assess whether these mice are less likely to develop behavioral deficits or express histological pathologies normally seen in untreated transgenics.

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