Non-thermal Histotripsy Tumor Ablation Promotes Abscopal Immune Responses that Enhance Cancer Immunotherapy
An international collaborative group based at the University of Michigan sought to determine whether histotripsy could create an anti-tumor immune response to melanoma or hepatocellular carcinoma in mice. Besides stimulating tumor-specific immune responses that appeared to synergize with checkpoint-based immunotherapeutics, their technique also may have created a systemic immune response that shrunk secondary untreated tumors and inhibited growth of pulmonary metastases.
Histotripsy-induced Immune Response
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