The Society for Neuroscience held its premier meeting, Neuroscience 2019, in Chicago from October 19-23. Twenty-five of the presentations featured focused ultrasound research in a variety of areas, including stem cell transplantation, blood-brain barrier opening, transcranial energy transmission (including intracerebral hemorrhage as a side effect), and targeted gene and nanoparticle delivery. Presenters also discussed using the technology to address epilepsy and essential tremor, and focused ultrasound—induced neuromodulation was a topic of interest.
“The Society for Neuroscience meeting is the world’s largest showcase for new ideas and methods in brain research,” shared Vincent Ferrera, PhD, Professor of Neuroscience (in Psychiatry) at Columbia University.
See a list of the focused ultrasound abstracts from the 2019 meeting below.
Neuroscience 2020 will be held October 24-28, 2020 in Washington, DC, and the abstract deadline is April 30, 2020.
2019 Abstracts
048.01. Increased transplantation efficacy of mesenchymal stem cell by focused ultrasound and improvement of the spatial memory in the 192 IgG-saporin rat model
J. LEE1,2, Y. SEO1,2, J. SHIN1,2, C. KONG1, Y. NA3, W. CHANG1, J. CHANG1,2
1Dept. of Neurosurg.,
2Brain Korea 21 PLUS Project for Med. Sci., Yonsei Univ. Col. of Med., Seoul, Korea, Republic of
3Dept. of Neurosurg., Catholic Kwandong Univ. Col. of Med., Incheon Metropolitan City, Republic of Korea
[Poster]
048.02. Molecular changes associated with noninvasive transplantation and homing of mesenchymal stem cells by focused ultrasound in the rat brain
Y. SEO1,2, J. LEE1,2, J. SHIN1,2, C. KONG1, Y. NA3, W. CHANG1, J. CHANG1,2
1Dept. of Neurosurg
2Brain Korea 21 PLUS Project for Med. Sci., Yonsei Univ. Col. of Med., Seoul, Korea, Republic of
3Dept. of Neurosurg., Catholic Kwandong Univ. Col. of Med., Incheon Metropolitan City, Republic of Korea
[Poster]
048.03. Changes in the level of P2X7 expression after focused ultrasound induced blood-brain barrier opening in the rat brain
J. SIM1,2, J. SHIN1,2, C. KONG2, J. LEE1,2, Y. NA3, W. CHANG2, J. CHANG1,2
1Brain Korea 21 Plus Project Med. Sci.
2Dept. of Neurosurg., Yonsei Univ. Col. of Med., Seoul, Korea, Republic of
3Dept. of Neurosurg., Catholic Kwandong Univ. Col. of Med., Incheon Metropolitan City, Republic of Korea
[Poster]
048.06. Optimizing skull penetration of focused ultrasound through analysis of energy efficiency for various skull factors
C. KONG1, J. SHIN1,2, Y. NA3, H. BEAK4, J. PARK4, W. CHANG1, J. CHANG1, J. CHANG2
1Dept. of Neurosurg.
2Brain Korea 21 PLUS Project for Med. Sci., Yonsei Univ. Col. of Med., Seoul, Korea, Republic of;
3Dept. of Neurosurg., Catholic Kwandong Univ. Col. of Med., Incheon Metropolitan City, Korea, Republic of
4Med. Device Develop. Ctr., Daegu-Gyeongbuk Med. Innovation Fndn., Daegu, Republic of Korea
[Poster]
048.07. The modulation of activity-regulated cytoskeleton associated protein expression in the rat hippocampus using focused ultrasound
J. SHIN1,2, C. KONG1, J. SIM1,2, J. LEE1,2, Y. SEO1,2, Y. NA3, W. CHANG1, J. CHANG1,2
1Dept. of Neurosurg.
2Brain Korea 21 PLUS Project for Med. Sci., Yonsei Univ. Col. of Med., Seoul, Korea, Republic of
3Dept. of Neurosurg., Catholic Kwandong Univ. Col. of Med., Incheon Metropolitan City, Republic of Korea
[Poster]
175.10. Influence of tight junction protein density on focused ultrasound-mediated blood-brain barrier permeability enhancement measured by dynamic contrast-enhanced MRI
D. MCMAHON1,2, K. HYNYNEN1,2
1Physical Sci., Sunnybrook Res. Inst., Toronto, ON, Canada
2Med. Biophysics, Univ. of Toronto, Toronto, ON, Canada
[Poster]
216.20. Focused ultrasound-induced intracerebral hemorrhage at two distinct pressures causes differing outcomes in mice
C. M. D. COLLIER1, H. ZHANG2, E. E. KONOFAGOU2, C. M. TROY3
1Neurobio. and Behavior
2Engin., Columbia Univ., New York, NY
3Dept Pathol & Neurol, Columbia Univ. Medl Ctr., New York, NY
[Poster]
218.12. Piezo2 is an ultrasound-sensitive ion channel that mediates neuromodulation in mammalian peripheral nerve
Y. BABA1, B. U. HOFFMAN1, C.-K. TONG1, E. E. KONOFAGOU2, E. A. LUMPKIN1
1Physiol. and Cell. Biophysics
2Biomed. Engin. & Radiology, Columbia Univ. Med. Ctr., New York, NY
[Poster]
220.12. Effects of external low intensity focused ultrasound on electrophysiological changes in vivo in a rodent model of common peroneal nerve injury
A. HELLMAN1, T. MAIETTA1, K. BYRAJU1, P. NEUBAUER2, E. WILLIAMS2, C. BURDETTE2, D. S. SHIN1, G. GHOSHAL2, J. QIAN3, J. NALWALK1, J. G. PILITSIS1
1Albany Med. Col., Albany, NY
2Acoustic Medsystems, Savoye, IL
3Albany Med. Ctr., Albany, NY
[Poster]
253.16. Noninvasive optogenetics using MRI guided focused ultrasound delivery of radioluminescent nanoparticles
M. C. RICH1, E. ZHANG2, M. K. BURDETTE2, A. DICKEY2, K. E. CANNON1, S. H. FOULGER2, M. S. BOLDING1
1Dept. of Radiology, Univ. of Alabama Birmingham, Birmingham, AL
2Dept. of Materials Sci. and Engin., Clemson Univ., Anderson, SC
[Poster]
254.16. Modulation of decision-making behavior by deep brain focused ultrasound stimulation in nonhuman primates
F. A. MUNOZ1, A. MEANEY1, K. LIU2, A. GROSS2, A. POULIOPOULOS3, E. KONOFAGOU2, V. P. FERRERA4
1Zuckerman institute
3Biomed. Engin.
4Neurosci.
2Columbia Univ., New York, NY
[Poster]
254.17. Ovine model assessment of sonication parameters on transcranial focused ultrasound-mediated neuromodulation
K. YOON1, W. LEE2, J. LEE2, L. XU2, S.-S. YOO2
1Radiol, Brigham & Women’s Hosp
2Harvard Med. Sch., Boston, MA
[Poster]
254.18. Focused ultrasound transiently increases membrane conductance in isolated crayfish axon
J.-W. LIN1, F. YU1, W. S. MÜLLER2, G. EHNHOLM3, Y. OKADA2
1Boston Univ., Boston, MA
2Div. of Newborn Med., Dept. of Med., Boston Children’s Hosp. and Harvard Med. Sch., Boston, MA
3Dept. of Neurosci. and Biomed. Engin., Aalto Univ., Aalto, Finland
[Poster]
254.20. Ultrasound suppression of seizures in 4-aminopyridine model of epilepsy
B. ELAHIAN1, C. SMITH1, P. O’BRIEN2, R. ARAVALLI2, D. DARROW3, E. EBBINI2, T. NETOFF1
1Biomed. Engin.
2Electrical and Computer Engin.
3Neurosurg., Univ. of Minnesota, Minneapolis, MN
[Poster]
341.03. Neurons have unequal sensitivity to transcranial ultrasound neuromodulation
X. NIU1, K. YU1, E. I. KROOK-MAGNUSON2, B. HE1
1Biomed. Engin., Carnegie Mellon Univ., Pittsburgh, PA
2Neurosci., Univ. of Minnesota Syst., Minneapolis, MN
[Poster]
433.03. Effects of low intensity focused ultrasound on motor cortex excitability in human
K.-H. S. CHEN1,2, A. FOMENKO3, J. SARAVANAMUTTU2, M. EL-BABA2, J.-F. NANKOO2, A. M. LOZANO4, R. CHEN5
1Natl. Taiwan Univ. Hosp. Hsin-Chu Br., Hsin-Chu, Taiwan
3Dept. of Neurosurg.
2Krembil Res. Inst., Toronto, ON, Canada
4Dept Neurosurg., Toronto Western Hosp. Rm 4-431 West, Toronto, ON, Canada
5Toronto Western Hosp, Toronto, ON, Canada
[Poster]
433.04. Non-invasive, receptor-specific, millimetre-precision manipulation of brain circuits for neuropsychiatric disorders
A. SHAH1, M. S. OZDAS1, P. M. JOHNSON1, N. PATEL1, M. MARKS1, T. YASAR1, W. VON DER BEHRENS1, S. R. SIRSI2, M. F. YANIK1
1ETH Zürich/Institute of Neuroinformatics, Zürich, Switzerland
2Bioengineering, UT Dallas, Richardson, TX
[Poster]
501.08. The neurovascular response is attenuated by focused ultrasound-mediated disruption of the blood-brain barrier
N. TODD1, Y. ZHANG1, M. S. LIVINGSTONE2, D. BORSOOK3, N. MCDANNOLD1
1Brigham and Women’s Hosp., Boston, MA
2Harvard Med. Sch., Boston, MA
3PAIN Res. Group, Boston Children’s Hosp., Boston, MA
[Poster]
555.11. Zebrafish model of post-traumatic epilepsy
S.-J. CHO1, E. PARK2, A. BAKER2, A. REID1
1Univ. Hlth. Network, Toronto, ON, Canada
2St. Michael’s Hosp., Toronto, ON, Canada
[Poster]
565.11. Targeted delivery of Huntington’s disease gene therapeutics
N. TODD1, B. ELMER2, K. B. KEGEL3, L. S. SHIHABUDDIN2, L. M. STANEK2, J. UPADHYAY4
1Radiology, Brigham and Women’s Hosp., Boston, MA
2Rare and Neurologic Dis. Therapeut. Area, Sanofi, Framingham, MA
3Neurol., Mass Gen. Hosp., Charlestown, MA
4Dept. of Anesthesiology, Critical Care and Pain Med., Boston Children’s Hospital, Harvard Med. Sch., Boston, MA
[Poster]
589.20. Focused ultrasound treatment of murine non-alcoholic steatohepatitis
T. S. HUERTA1, A. DEVARAJAN1, T. TSAAVA1, S. S. CHAVAN1,2,3, K. J. TRACEY1,2,3
1Lab. of Biomed. Sci., Feinstein Inst. for Med. Res., Manhasset, NY
2Elmezzi Grad. Sch. of Mol. Med., Manhasset, NY
3Donald and Barbara Zucker Sch. of Med. @ Hofstra/Northwell, Hempstead, NY
[Poster]
615.17. A multiscale modeling framework to understand and optimize ultrasound neuromodulation
T. LEMAIRE1, E. NEUFELD2, S. MICERA1
1Translational Neural Engin. Lab., Ecole Polytechnique Federale De Lausanne, Lausanne, Switzerland
2Computat. Life Sci., IT’IS Fndn., Zuerich, Switzerland
[Poster]
643.09. Cerebellar GluRδ2 deficiency in mice recapitulates key clinical features of essential tremor
C.-L. NI1, M.-K. PAN3, Y.-S. LI1, S.-B. WANG4, E. P. CORTES5, J. G. VONSATTEL2, E. D. LOUIS6, P. L. FAUST2, S.-H. KUO1
1Dept. of Neurol.
2Departments of Pathology and Cell Biol., Columbia Univ., New York, NY
3Dept. of Med. Res., Natl. Taiwan Univ. Hosp., Taipei, Taiwan
4Dept. of Pediatrics, Taipei Tzu Chi Hosp., Taipei, Taiwan
5Dept. of Pathology, Icahn Sch. of Med. at Mount Sinai, New York, NY
6Dept. of Neurol., Yale Univ., New Haven, CT
[Poster]
677.05. Magnetic resonance-guided focused ultrasound-mediated gene therapy delivery to brain tissue post-surgical resection
M. A. STAVARACHE, G. M. WINSTON, M. YUAN, A. ZANELLO, E. M. JURGENS, M. G. KAPLITT
Neurosurg., Weill Cornell Med. Col., New York, NY
[Poster]
747.05. Techniques for spinal cord stimulation to restore bladder function in rats
S. J. ILHAM1, N. NOLTA1, C. HARDY2, P. SMITH2, M. HAN1
1Biomed. Engin., Univ. of Connecticut, Storrs Mansfield, CT
2Univ. of Connecticut Hlth., Farmington, CT
[Poster]