Depression Clinical Trial Opens in Canada

Focused Ultrasound Clinical Trial for Depression Begins in Toronto

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In a North American first, researchers at Sunnybrook Health Sciences Centre in Toronto have launched a pilot clinical trial to determine the safety, feasibility, and preliminary efficacy of using focused ultrasound to help patients with treatment-resistant major depression.

The trial will use focused ultrasound to disrupt a key circuit in the brain long associated with major depression, by destroying a 5mm structure known as the anterior limb of the internal capsule.

“Clinicians have used neurosurgical techniques such as radiofrequency ablation, radiosurgery, and deep brain stimulation of this target in the brain and have had success in alleviating symptoms of depression,” said Neal F. Kassell, MD, chairman of the Focused Ultrasound Foundation. “Focused ultrasound is an alternative method that could produce the same results noninvasively and without the harmful effects or complications of radiation or surgery, while decreasing the cost of care.”

“Although we are in the early stages of investigating the safety and efficacy of focused ultrasound for patients with depression, it has the potential to be another treatment option, and expand the number of patients who can be treated,” says Dr. Nir Lipsman, principal investigator of the trial, and Director of the Harquail Centre for Neuromodulation at Sunnybrook.

Six patients will be treated in the trial using Insightec’s Exablate Neuro device. Patients will be assessed for severity of depression and level of functioning at one, three, six, and 12 months post-treatment.

This trial follows a similar one completed in Seoul, Korea, published in Biological Psychiatry.

The trial at Sunnybrook will be funded in part by the Foundation and builds upon the Canadian site’s impressive portfolio of research in focused ultrasound for brain disorders. In November 2016, Sunnybrook was designated as one of the Foundation’s Centers of Excellence.

Read Sunnybrook’s press release >

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