Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma

Project Name: Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma
Status: Complete
Primary Site: Brigham and Women's Hospital
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: May 17, 2017
Funding Program: Immunotherapy
Funding Period: May 17, 2017 - Nov 17, 2017
Amount Awarded: $112,955.43
Category: Brain tumors, Glioblastoma

Abstract

The recent success of immunotherapies in cancers such as melanoma has spurred interest in the application of these therapies for other cancers. Glioblastoma (GBM) affects an estimated 18,500 patients annually, and there are approximately 15,000 deaths per year from GBM in the US. GBM is a highly invasive and diffuse tumor, commonly occurring in white matter. There are no clear margins between tumor and brain tissue, which makes full surgical resection impossible. 90% of patients develop tumor recurrence at or near the surgical site. Recent work has demonstrated that immunotherapies can have a beneficial effect in mouse models of GBM and metastatic brain cancer. This effect could be augmented by using focused ultrasound to increase the immunogenicity or accessibility of the tumors, thereby increasing the infiltration and/or activity of anti-tumor immune cells. In this study we want to investigate the effects of different focused ultrasound modalities on the immune system. Each of these modalities will be investigated by a site with expertise in the field

Contact Roles

Reports

No reports found.

Clinical Trials

The Focused Ultrasound Foundation Newsletter

Our newsletter delivers updates for clinicians, researchers and patients. Sign up and stay on top of the rapid advancements of this innovative medical technology.

Sign Up  Read the Latest Issue

Read The Tumor  by John Grisham

From John Grisham, comes a story where today’s medical fiction could become tomorrow’s lifesaving reality.

Download a Free eBook or Audiobook

Contact Details

Call Us
434.220.4993
Find Us
Focused Ultrasound Foundation
1230 Cedars Court, Suite 206 Charlottesville, VA 22903
Email