K. Hynynen et al. determined that focused ultrasound, combined with microbubbles, can cause localized and reversible disruption of the blood brain barrier (BBB), a historically major obstacle in the treatment of brain diseases.

G. Clement and K. Hynynen demonstrated noninvasive focusing through human skull using a phased array and CT based planning algorithm.

In 2006, M. Kinoshita et al. demonstrated antibody delivery through the BBB using MRgFUS.

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